Concentrating on intrinsic disorder
نویسندگان
چکیده
منابع مشابه
SnapShot: Intrinsic Structural Disorder
Many proteins (intrinsically disordered proteins, IDPs) or regions of proteins (intrinsically disordered regions, IDRs) lack a well-defined 3D structure under physiological conditions. Albeit unfolded and highly dynamic, these proteins are not denatured; rather, intrinsic structural disorder is their native, functional state.
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The recent advances in the prediction of intrinsically disordered proteins and the use of protein disorder prediction in the fields of molecular biology and bioinformatics are reviewed here, especially with regard to protein function. First, a close look is taken at intrinsically disordered proteins and then at the methods used for their experimental characterization. Next, the major statistica...
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Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) are new exciting members of the protein kingdom. They are highly abundant in nature, possess numerous intriguing properties, are intimately involved in various cellular processes and are commonly found to be related to the pathogenesis of various diseases. The common theme of protein disorder-based fun...
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Intrinsic disorder (ID) is highly abundant in eukaryotes, which reflect the greater need for disorder-associated signaling and transcriptional regulation in nucleated cells. Although several well-characterized examples of intrinsically disordered proteins in transcriptional regulation have been reported, no systematic analysis has been reported so far. To test for the general prevalence of intr...
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To some extent contradicting the classical paradigm of the relationship between protein 3D structure and function, now it is clear that large portions of the proteomes, especially in higher organisms, lack a fixed structure and still perform very important functions. Proteins completely or partially unstructured in their native (functional) form are involved in key cellular processes underlain ...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2018
ISSN: 1471-0072,1471-0080
DOI: 10.1038/s41580-018-0039-5